A domain name is an identification string that defines a realm of administrative autonomy, authority or control within the Internet. Domain names are used in various networking contexts and for application-specific naming and addressing purposes. In general, a domain name identifies a network domain, or it represents an Internet Protocol (IP) resource, such as a personal computer used to access the Internet, a server computer hosting a web site, or the web site itself or any other service communicated via the Internet. In 2017, 330.6 million domain names had been registered.
One of the most important compatibility factors to consider with email is the mobility question. How often do your employees need to access email via mobile devices? That's an important issue because most email hosting providers deliver some kind of web client usable as a default inbox. Almost all of these can be accessed via a mobile device, so if your employees don't need to access their emails on the road that much, then such mediocre clients are probably fine.